I-Formamidine acetate, eyaziwa nangokuthi i-N, N-dimethylformamidine acetate noma i-CAS No. 3473-63-0, iyinhlanganisela ebalulekile edlala indima ebalulekile ekuthuthukiseni izidakamizwa.Le khemikhali idonse ukunakwa okukhulu embonini yezemithi ngenxa yezakhiwo zayo eziningi kanye nezinhlelo zokwelapha ezingase zibe khona.
Enye yezinto ezibalulekile ze-formamidine acetate yikhono layo lokusebenza njengesisekelo esiqinile kanye ne-nucleophile.Lokhu kusho ukuthi ingabamba iqhaza ngokugcwele ekuphenduleni kwamakhemikhali, okuyenza ibe yingxenye ebalulekile ekuhlanganisweni kwemithi eminingi.Ukusebenza kwayo okuyingqayizivele kuvumela ukuthi isetshenziswe ezinhlobonhlobo zezicelo zemithi, okuhlanganisa ukuthuthukiswa kwezidakamizwa ezilwa namagciwane, i-antibacterial kanye ne-antifungal.
I-Formamidine acetateibonise amandla amakhulu njenge-ejenti elwa namagciwane.Umsebenzi wayo omelene namagciwane e-DNA kanye ne-RNA, okuhlanganisa i-herpes simplex virus (HSV) kanye ne-human immunodeficiency virus (HIV), uye wacwaningwa kabanzi.Abacwaningi bathola ukuthi i-compound ivimbela ukuphindaphinda kwegciwane ngokuphazamisa ama-enzyme egciwane, ngaleyo ndlela ivimbele amandla abo okuphindaphinda ngaphakathi kwamaseli aphethe.Njengoba kunikezwe ukukhathazeka okukhulayo mayelana nokuqubuka kwegciwane kanye nesidingo sokwelashwa okuphumelelayo kwe-antiviral, i-formamidine acetate kulindeleke ukuthi ibe yikhandidethi elingase libe khona ekuthuthukisweni kwemishanguzo ye-antiviral inoveli.
Ngaphezu kwalokho, i-formamidine acetate ibonise izakhiwo ezinamandla ze-antimicrobial.Kuye kwacwaningwa ngokusebenza kwayo ngokumelene nezinhlobo ezihlukahlukene zamagciwane, kokubili i-Gram-positive ne-Gram-negative.Ucwaningo luye lwabonisa ukuthi le nhlanganisela ingaphazamisa ulwelwesi lwamangqamuzana e-bacterial, luvimbele ukukhula kwamagciwane kanye nokuzala.Kuphinde kwatholakala ukuthi ithuthukisa ukusebenza kwemithi elwa namagciwane, iyenze ibe isithasiselo esingaba khona ekulweni namagciwane amelana nama-antibiotic.
Esinye isicelo esibalulekile sei-formamidine acetateilele emandleni ayo e-antifungal.Ukutheleleka kwe-fungal kuyingozi enkulu empilweni yabantu, ikakhulukazi kubantu abangenawo amandla omzimba.I-compound ibonise imiphumela ethembisayo ekuvimbeleni ukukhula kwesikhunta se-pathogenic ngokuphazamisa ulwelwesi lwamangqamuzana abo futhi luphazamise izindlela zabo ze-metabolic.Njengoba ukumelana nesikhunta emithini yamanje ye-antifungal kuya ngokuya kuvame, i-formamidine acetate inikeza indlela entsha yokwakhiwa kwemithi elwa namagciwane.
I-Formamidine acetate nayo isetshenziswa njengesihluthulelo esimaphakathi ekuhlanganisweni kwezinhlanganisela eziningi zemithi.Isakhiwo sayo samakhemikhali esiyingqayizivele kanye nokusebenza kabusha kuyenza ibe impahla eluhlaza efanelekile yokukhiqizwa kwemithi ehlukahlukene.Ngaphezu kwalokho, ukuhlanganiswa kwayo okuphumelelayo nokufinyeleleka kunomthelela ekwazisweni kwayo ekuthuthukisweni kwezidakamizwa.
Ekuphetheni,i-formamidine acetatengenombolo ye-CAS 3473-63-0 idlala indima ebalulekile ekuthuthukisweni kwezidakamizwa.Ikhono layo lokusebenza njengesisekelo esiqinile kanye ne-nucleophile, kanye nezakhiwo zayo ezinamandla zokulwa namagciwane, i-antibacterial, kanye ne-antifungal, kuyenza ibe ikhandidethi elikhangayo ekuthuthukisweni kwama-agent okwelapha anoveli.Ukuhlolwa okuqhubekayo kwe-formamidine acetate ocwaningweni lwezemithi kuletha ithemba elikhulu lokutholakala kwezidakamizwa esikhathini esizayo kanye nokwelashwa kwezifo ezihlukahlukene ezithathelwanayo.
Isikhathi sokuthumela: Jun-20-2023