I-DMTCl44′Dimethoxytrityl CAS 40615-36-9
Sethula i-DMTCl4 4' Dimethoxytrityl - ikhambi eliwujuqu lokuvikela iqembu eliphumelelayo, ukuqedwa kanye nokuvikelwa kwe-hydroxyl kwama-nucleoside nama-nucleotide.Ngokuhlanzeka kwayo okukhethekile ≥ 98%, le crystal ephinki ephaphathekile ilungele wonke amaphrojekthi akho ocwaningo nentuthuko.
Chemical Properties
Ukugcina, i-DMTCl4'Dimethoxytrityl idinga izinga lokushisa elingu-2 ukuya ku-8°C ukuze lizinze kahle.Kodwa-ke, ngenxa yokuhlanzeka kwayo okuphezulu, ingagcinwa isikhathi eside ngaphandle kokuwohloka noma ukulahleka kwekhwalithi.
Izinhlelo zokusebenza
I-DMTCl44'Dimethoxytrityl iyi-ejenti yokuvikela yeqembu ephumelela kakhulu eklanyelwe ukuvikela amaqembu asebenzayo kumakhompawundi ezinto eziphilayo njengama-amine, ama-carboxyl notshwala.Isetshenziswa kabanzi ku-organic synthesis kanye ne-peptide chemistry ukuze kuvikelwe ama-amine ayisisekelo nesesibili kuma-reagents ahlukahlukene.
Ngaphezu kwamakhono ayo okuvikela iqembu, i-DMTCl44'Dimethoxytrityl futhi iyisinqamuli esingasetshenziswa ukususa amaqembu e-hydroxyl kuma-nucleotide noma ama-nucleoside.Lokhu kuwusizo ikakhulukazi ekuhlanganiseni ama-nucleotide analogues, lapho ukuba khona kwamaqembu e-hydroxyl kungaholela ekuphenduleni okungafuneki ohlangothini.
Ngaphezu kwalokho, i-DMTCl44'Dimethoxytrityl isebenza njenge-ejenti enhle kakhulu yokuvikela i-hydroxyl kuma-nucleoside nama-nucleotide.Ivikela amaqembu e-hydroxyl endaweni engu-3' noma engu-5' ye-ribonucleosides noma i-deoxyribonucleosides ekuphenduleni okungafunwa.
Kafushane, uma ufuna izivikeli zeqembu ezisebenza kahle kakhulu, izinqamuli kanye nezivikeli ze-hydroxyl zama-nucleoside nama-nucleotide, asikho isisombululo esingcono kune-DMTCl4 4' Dimethoxytrityl.Ngokuhlanzeka kwayo okukhethekile, ukubekeka kalula kanye nohlu olubanzi lwezinhlelo zokusebenza, i-DMTCl4 4' Dimethoxytrityl ilungele zonke izidingo zakho ze-organic synthesis kanye ne-peptide chemistry.