I-Dimethoxytrityl, ngokuvamile eyaziwa ngokuthi i-DMTCl44, iyinhlanganisela eye yasetshenziswa kabanzi ekuhlanganiseni izinto eziphilayo amashumi eminyaka ambalwa.Ngeqembu layo eliphumelelayo elivikelayo, eliqeda, kanye nezakhiwo ezivikela i-hydroxyl, i-DMTCl44 isibe yithuluzi elibalulekile labacwaningi nosokhemisi abasebenza emkhakheni wama-nucleosides nama-nucleotide.
Inombolo ye-CAS:40615-36-9, i-DMTCl44 iyimpushana ecwebezelayo emhlophe encibilika kuzincibilikisi ezivamile ezifana ne-methanol, i-acetone, ne-chloroform.Izinzile ngaphansi kwezimo ezijwayelekile futhi ingagcinwa isikhathi eside ngaphandle kokuwohloka.Ukuthandwa kwayo emphakathini wesayensi kungabangelwa izakhiwo zayo eziyingqayizivele kanye nezinhlelo zokusebenza ezihlukahlukene.
Enye yezindlela eziyinhloko ezisetshenziswa ngayo i-DMTCl44 njengeqembu elivikelayo ku-organic synthesis.Ngokuvamile isetshenziselwa ukuvikela amaqembu e-hydroxyl kuma-nucleosides nama-nucleotides.Ngokuvikela okwesikhashana lawa masayithi asebenzayo, i-DMTCl44 ivumela osokhemisi ukuthi benze ukusabela okuthile ngaphandle kokusabela okuseceleni okungadingeki.Leli khono libaluleke kakhulu ekuhlanganiseni ama-molecule ezinto eziphilayo eziyinkimbinkimbi, ikakhulukazi ekuthuthukisweni kwemithi.
Ngaphezu kwezakhiwo zayo zokuvikela iqembu, i-DMTCl44 futhi isebenza njenge-ejenti yokuqeda.Kwenza kube lula ukususwa kwamaqembu avikelayo angafunwa, ekugcineni kuvezwe ukwakheka kwamangqamuzana adingekayo.Lesi sici sibalulekile ezinqubweni zokuhlanganiswa kwezinyathelo eziningi, lapho ukuvikela kwesikhashana kuyadingeka ezinyathelweni eziphakathi nendawo.
I-DMTCl44iyi-ejenti evikela i-hydroxyl esebenza ngempumelelo yama-nucleosides nama-nucleotide.Yakha ama-complexes azinzile nalawa ma-molecule, ivimbela ukusabela okungafuneki ngesikhathi sokuxhaphazwa kwamakhemikhali.Ukuvikelwa kwamaqembu e-hydroxyl kubalulekile ekuhlanganisweni kwama-nucleosides ashintshiwe, asetshenziswa kakhulu ekwakhiweni kwemithi elwa namagciwane kanye nokwelapha okusekelwe ku-nucleic acid.
Izakhiwo ezihlukile ze-DMTCl44 ziholele ekusebenziseni kwayo kabanzi emikhakheni eyahlukene ye-organic synthesis.Kusukela embonini yezemithi kuya ocwaningweni lwe-nucleic acid, i-DMTCl44 idlala indima ebalulekile ekuxazululeni izindida zamakhemikhali eziyinkimbinkimbi kanye nokuzuza izakhiwo zamangqamuzana ezifiselekayo.
Embonini yezemithi,I-DMTCl44ivame ukusetshenziswa ekuhlanganisweni kwezidakamizwa ezilwa namagciwane kanye ne-nucleic acid-based therapeutics.Ngokuvikela nokushintsha ama-nucleosides, osokhemisi bangaklama ama-molecule anezindawo zokwelapha ezithuthukisiwe kanye nezinhlelo zokulethwa kwezidakamizwa ezihlosiwe.Ngaphezu kwalokho, i-DMTCl44 inika amandla ukuhlanganiswa okuphumelelayo kwama-nucleic acids ashintshiwe, njengama-nucleic acids akhiyiwe (LNAs) nama-peptide nucleic acids (PNAs), abonise isithembiso esibalulekile ekusetshenzisweni okuhlukahlukene kokwelapha.
Ngale kwesayensi yezemithi, i-DMTCl44 ithola usizo ocwaningweni lwesayensi olufaka ama-nucleic acid.Ivumela abacwaningi ukuba bashintshe futhi bahlole ama-nucleoside nama-nucleotide, bembule ubunkimbinkimbi balezi zakhi ezibalulekile zokuphila.Lokhu kuqonda kubalulekile ekuthuthukiseni ulwazi lwethu emikhakheni efana nezakhi zofuzo, i-genomics, kanye nebhayoloji yamangqamuzana.
Ekuphetheni,I-DMTCl44, eyaziwa nangokuthi i-Dimethoxytrityl, iyinhlanganisela eguquguqukayo eye yashintsha ukwakheka kwezinto eziphilayo, ikakhulukazi emikhakheni yama-nucleosides nama-nucleotide.Iqembu layo elisebenzayo elivikelayo, eliqeda, kanye nezakhiwo ezivikela i-hydroxyl likwenze kwaba ithuluzi elibaluleke kakhulu kosokhemisi nabacwaningi emhlabeni wonke.Ngokuqonda izakhiwo eziyingqayizivele kanye nokusetshenziswa okuhlukahlukene kwe-DMTCl44, singaqhubeka nokuvula izimfihlakalo zamakhemikhali ezinto eziphilayo futhi sithuthukise ulwazi lwesayensi ezizindeni ezihlukahlukene.
Isikhathi sokuthumela: Sep-19-2023