I-Dimethoxytrityl (DMTCl44)iyinhlanganisela enamandla futhi eguquguqukayo esetshenziswa kabanzi kukhemistri ephilayo njengeqembu eliphumelelayo elivikelayo, i-ejenti yokuqeda, ne-agent evikela i-hydroxyl yama-nucleosides nama-nucleotide.Izakhiwo zayo eziyingqayizivele kanye nezinhlelo zokusebenza ezihlukahlukene zikwenze kwaba ithuluzi elibalulekile emkhakheni wokuhlanganiswa kwamakhemikhali.
I-DMTCl44, enefomula yamakhemikhali ethi C28H23Cl2NO2, yaziwa kakhulu nge-Dimethoxytrityl chloride.Inenombolo ye-CAS ye-40615-36-9 futhi yaziswa kakhulu ngekhono layo lokuvikela nokusebenzisa amaqembu ahlukahlukene asebenzayo, ngaleyo ndlela ivumele ukuhlanganiswa kwama-molecule ayinkimbinkimbi ngokunemba nokusebenza kahle.
Esinye sezici ezibalulekile zeI-DMTCl44amandla ayo okuvikela amaqembu e-hydroxyl, ikakhulukazi kuma-nucleoside nama-nucleotide.Lezi zinhlanganisela zidlala indima ebalulekile ekuhlanganiseni kwe-DNA ne-RNA, futhi ukuvikelwa kwazo kubalulekile ukuze kulondolozwe ukuzinza kwazo phakathi noshintsho oluhlukahlukene lwamakhemikhali.I-DMTCl44 ivikela ngempumelelo iqembu le-hydroxyl, ivimbele ukusabela okungafuneki futhi ivumele ukuguqulwa okukhethiwe ukuthi kwenzeke kwamanye amaqembu asebenzayo.
Ngaphezu kwalokho, i-DMTCl44 isebenza njenge-ejenti yokuqeda ephumelelayo noma i-ejenti evikelayo.Kwenza kube lula ukususwa kwamaqembu avikelayo uma ukuguqulwa kwamakhemikhali okufunayo sekufinyelelwe.Lesi sici sibaluleke kakhulu ekuhlanganiseni kwezinyathelo eziningi, lapho amaqembu avikelayo edinga ukususwa ngokukhetha ukuze kuvezwe amasayithi asebenzayo ukuze kuqhutshekwe noshintsho.Ikhono le-DMTCl44 lokuqeda amaqembu avikelayo ngokukhetha nangempumelelo liye lashintsha umkhakha wamakhemikhali ezinto eziphilayo, okwenza abacwaningi bakwazi ukuhlola imizila yokwenziwa eyinkimbinkimbi futhi bakhe ama-molecule amasha anemisebenzi yebhayoloji ethuthukisiwe.
Ukusabela koguquko okwenziwa yi-DMTCl44 kuningi.Isetshenziswa kabanzi ekuhlanganiseni ama-nucleoside nama-nucleotide analogues, abalulekile ekutholakaleni nasekuthuthukisweni kwezidakamizwa.Ngokuvimba ngamasu amaqembu athile asebenzayo, osokhemisi bangakwazi ukuxhaphaza ukusebenza kabusha kwalezi zinhlanganisela ukuze bakhe ama-analogue anoveli anezakhiwo ezithuthukisiwe zemithi.Indima ye-DMTCl44 njenge-ejenti evikela i-hydroxyl ibalulekile kulezi zinqubo, njengoba iqinisekisa ukulondolozwa komsebenzi ofunekayo webhayoloji kuyilapho ivumela ukuguqulwa kwezinye izikhundla.
I-DMTCl44futhi ithola usizo ekuhlanganiseni kwe-peptide, ikakhulukazi ekuvikelweni kwama-amino acid ngesikhathi sokuhlanganiswa kwe-peptide yesigaba esiqinile.Ama-amino acid aqukethe amaqembu amaningi asebenzayo angaholela ekuphenduleni okungafuneki ohlangothini ngesikhathi sokuhlanganiswa.Ngokusebenzisa i-DMTCl44 njenge-ejenti evikela iqembu, osokhemisi bangakwazi ukulawula ukusebenza kabusha futhi ngokukhetha bavikele amaqembu athile asebenzayo, okuvumela ukuhlangana okuhamba kancane kwama-peptide ngobumsulwa obukhulu kanye nesivuno.
Ngokungeziwe ekusebenziseni kwayo emkhakheni we-synthesis, i-DMTCl44 ibe negalelo entuthukweni ebalulekile kukhemikhali yemvelo.Ukusetshenziswa kwayo njengeqembu elivikelayo kuye kwavumela ukuthuthukiswa nokuhlanganiswa kwemikhiqizo yemvelo ehlukahlukene, imithi, nama-molecule e-bioactive.Ivule izindlela ezintsha zokuklama nokuhlanganiswa kwezidakamizwa ezintsha, amasistimu we-catalytic, nezinto zokusebenza.
Ekuphetheni,I-Dimethoxytrityl (DMTCl44)kuvele njengethuluzi elibalulekile emhlabeni we-organic chemistry.Iqhaza layo njenge-ejenti evikelayo yeqembu, i-ejenti yokuqeda, ne-ejenti evikela i-hydroxyl ibe negalelo elikhulu ekuthuthukisweni kokusabela kwamakhemikhali kanye nokuthuthukiswa kwama-molecule amasha.Izakhiwo zayo ezihlukile kanye nokusetshenziswa okuhlukahlukene kuyenza i-reagent ebalulekile emikhakheni eyahlukene, okuhlanganisa nemithi, i-biochemistry, kanye nesayensi yezinto zokwakha.Njengoba abacwaningi bejula emhlabeni othakazelisayo we-DMTCl44, kuqinisekile ukuthi ukusabela okuguquguqukayo okwengeziwe kanye nezinhlelo zokusebenza ezintsha kuzotholakala, kuqhubeke kuphushe imingcele ye-organic chemistry.
Isikhathi sokuthumela: Sep-26-2023